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Why did the siGENOME products for my gene of interest change?

In order to keep current with ever-changing genetic data, as well as providing our customers with the best siRNA designs available, we carried out product line-wide analysis to determine (a) if all of our siGENOME siRNAs target the most current RefSeq records, including all new gene variants and (b) if any of the siGENOME siRNAs contain conserved miRNA seed region motifs that could cause off-target effects. If either of the above criteria necessitated a change, we redesigned the siRNA in question with our SMARTselection algorithm, which includes the latest in seed-region filters and frequency analysis to reduce seed region-related off-targets.