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PerkinElmer and Horizon Discovery

Western blotting reagents now available

Confirm your next loss-of-function experiment with our newly available suite of downstream analysis products from PerkinElmer.

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Gene Editing

Explore Gene Editing CRISPR guide RNA Cas9 nucleases Controls Custom guide RNA Knock-in templates Cherry-pick library tool CRISPR libraries

Gene Knockdown

Explore Gene Knockdown siRNA shRNA microRNA Controls lncRNA Custom siRNA design Cherry-pick library tool RNAi libraries

CRISPR Modulation

Explore CRISPR Modulation CRISPRi CRISPRa CRISPRa libraries dCas9 stable cell lines Controls

Gene Expression

Explore Gene Expression CRISPRa cDNAs ORFs cDNA/ORF libraries

Cell Line Engineering

Explore Cell Line Engineering Build your own cell line Knockout cell lines Cancer related cell lines Cas9 stable cell lines dCas9 stable cell lines

Custom Synthesis

Explore Custom Synthesis Single-strand RNA synthesis Custom siRNA Custom DNA Custom microRNA

Reference Standards

Explore Reference Standards Oncospan Analysis technique Sample type Format Custom reference standards

Downstream Analysis

Explore Downstream Analysis Western blotting supplies Cellular imaging reagents Luminescence assays Fluorescent nucleotides & haptens Microplates

Transfection and Ancillary Reagents

Bioproduction Cell Lines

Explore Bioproduction Cell Lines CHOSOURCE expression platform

Functional Genomic Screening

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Screening platforms

CRISPR screens RNAi screens Arrayed screens Immune cell screens Pooled screens Single-cell CRISPR screens CHOSOURCE screens

Cell Panel Screening

Explore Cell Panel Screening 2D OncoSignature 3D OncoSignature Custom screens

Cell Line Engineering

Explore Cell Line Engineering Knockout Knock-in CHO cell engineering Build your own cell lines

Immunology Services

Explore Immunology Services Mixed Lymphocyte Reaction assay Immune cell screens

Contract Research Services

Custom Reference Standards

Custom Libraries

Custom Synthesis

Gene Editing

Explore Gene Editing Engineering a knockout cell line Synthetic sgRNA for CRISPR-Cas9 experiments CRISPR-Cas9 guide RNA functionality CRISPR-Cas9 guide RNA specificity Inducible lentiviral Cas9 nuclease Homology-directed repair with a DNA donor oligo Homology-directed repair with a plasmid donor Multiplex CRISPR-Cas9 knockout Single-reagent CRISPR knockout Synthetic lethality

CRISPRmod

Explore CRISPRmod CRISPR interference CRISPR activation CRISPRa MS2 tracrRNA

RNA Interference

Explore RNA Interference siRNA Self-delivering siRNA shRNA microRNA Noncoding RNA

Engineered Cell Lines

Explore Engineered Cell Lines Antibody validation Autophagy pathway Bromodomain containing proteins Caspases Deubiquinating enzymes (DUBs) DNA damage pathways Drug targets Epigenetics Histone acetylation Kinase inhibition mtor pathway Parkinson's disease Phosphoinositide function Phospholipases Primary and stem cells Rab GTPases Serine threonine phosphatase Sialylation pathway Solute carrier slc gene Sumoylation TNF alpha Ubiquitin conjugating enzymes

Functional Genomic Screening

Explore Functional Genomic Screening Screening validation and follow-up using engineered cell lines Reverse transfection for high-throughput CRISPR studies C911 controls for siRNA screening Seed sibling controls for RNAi hit validation

cDNA/ORF Overexpression

Custom RNA synthesis

Transfection

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Document Library

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Technical resources

Application notes Technical manuals Protocols Certificate of analysis Exome data Posters Publications Quick protocols Reading lists Safety data sheets Product data

Supporting resources

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Education & Events

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On the Horizon Blog

Explore On the Horizon Blog Gene editing Gene modulation Cell models Screening Reference standards Tech Tips

Tools & Calculators

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Biochemical conversion tools

OD conversion DNA copy number calculator

Reagent calculator

siRNA/miRNA calculator for screening DharmaFECT calculator for screening

BioIT beta tools

P-value to Z-score converter T7EI calculator nmol to µg calculator

Primer design & Analysis tools

Multiple primer analyzer TM calculator

qPCR

qpcr efficiency calculator

FAQs

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Products & Services FAQs

Explore Products & Services FAQs Gene editing Screening Cell lines Reference standards Custom Synthesis Transfection & transduction Viral packaging

Ordering & Shipping

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Account

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Custom Ordering Tools

Explore Custom Ordering Tools CRISPR design tool HDR donor design Custom siRNA siDESIGN center Cherry-pick libraries Custom microRNA Custom SMARTpool ssRNA synthesis Custom DNA

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Engineered cell lines
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1. Modification

Knockout

Single gene knockout

Double gene knockout

Knock-in

Point mutation (SNP)

Single gene tag/reporter knock-in

Single gene large knock-in

Cas9: Random integration

iPSC

Single gene knockout

Point mutation (SNP)

Single gene tag/reporter knock-in

Single gene large knock-in

Other

Primary cells, T cells, etc.

2. Gene

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3. Cell line

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3. Your primary T cell editing project

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