The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011].
Cancer-related cell lines
Choose from over 300 knock-in and knockout cell line models in many standard cancer cell lines such as DLD1, MCF10A, and HCT116.
Recapitulate disease phenotypes
Endogenous knock-in cell lines enable a clear understanding of a gene or mutation’s contribution to a phenotype including conditional knockouts to model human disease
Confirm your results
We provide truly isogenic cell line pairs. Each cell model comes with the parental cell line as an additional control
Knockout and knock-in models
Our knock in models have more complex genetic modifications such as:
- insertions
- base pair changes
- deletions
- truncations
- FLAG-tagged proteins for purification
Proven models
Our catalog of cell lines has become a gold-standard resource
in antibody validation, cancer research, and early drug-discovery research. Horizon was recently recognized by CiteAb as the Cell Line Supplier to Watch in Cancer Research for 2024. Read more about the CiteAb award.
Limited use agreement
All cell lines engineered by Horizon Discovery are purchased under the terms of our Limited Use Label License.