Cancer-related cell lines

Choose from over 300 knock-in and knockout cell line models in many standard cancer cell lines such as DLD1, MCF10A, and HCT116.

ATR ( Human )

Entrez Gene 545 entrezgene 545
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ATR serine/threonine kinase

Alias

FCTCS | FRP1 | MEC1 | SCKL | SCKL1

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008].

Recapitulate disease phenotypes

Endogenous knock-in cell lines enable a clear understanding of a gene or mutation’s contribution to a phenotype including conditional knockouts to model human disease

Confirm your results

We provide truly isogenic cell line pairs. Each cell model comes with the parental cell line as an additional control

Knockout and knock-in models

Our knock in models have more complex genetic modifications such as:

  • insertions
  • base pair changes
  • deletions
  • truncations
  • FLAG-tagged proteins for purification

Proven models

Our catalog of cell lines has become a gold-standard resourceciteab-award-cell-line-supplier-to-watch-in-cancer-research in antibody validation, cancer research, and early drug-discovery research. Horizon was recently recognized by CiteAb as the Cell Line Supplier to Watch in Cancer Research for 2024. Read more about the CiteAb award.

 

Limited use agreement

All cell lines engineered by Horizon Discovery are purchased under the terms of our Limited Use Label License.