Cancer-related cell lines

Choose from over 300 knock-in and knockout cell line models in many standard cancer cell lines such as DLD1, MCF10A, and HCT116.

MAP2K1 ( Human )

Entrez Gene 5604 entrezgene 5604
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mitogen-activated protein kinase kinase 1

Alias

CFC3 | MAPKK1 | MEK1 | MKK1 | PRKMK1

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008].

Recapitulate disease phenotypes

Endogenous knock-in cell lines enable a clear understanding of a gene or mutation’s contribution to a phenotype including conditional knockouts to model human disease

Confirm your results

We provide truly isogenic cell line pairs. Each cell model comes with the parental cell line as an additional control

Knockout and knock-in models

Our knock in models have more complex genetic modifications such as:

  • insertions
  • base pair changes
  • deletions
  • truncations
  • FLAG-tagged proteins for purification

Proven models

Our catalog of cell lines has become a gold-standard resourceciteab-award-cell-line-supplier-to-watch-in-cancer-research in antibody validation, cancer research, and early drug-discovery research. Horizon was recently recognized by CiteAb as the Cell Line Supplier to Watch in Cancer Research for 2024. Read more about the CiteAb award.

 

Limited use agreement

All cell lines engineered by Horizon Discovery are purchased under the terms of our Limited Use Label License.