HAP1 knockout cell lines

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HAP1 Parental Cell Lines available

VAC14 ( Human )

Entrez Gene 55697 entrezgene 55697
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Vac14, PIKFYVE complex component

Alias

ArPIKfyve | TAX1BP2 | TRX

This gene encodes a scaffold protein that is a component of the PIKfyve protein kinase complex. This complex is responsible for the synthesis of phosphatidylinositol 3,5-bisphosphate, an important component of cellular membranes, from phosphatidylinositol 3-phosphate. Mice lacking a functional copy of this gene exhibit severe neurodegeneration. Mutations in the human gene have been identified in patients with a childhood onset progressive neurological disorder characterized by impaired movement, dystonia, and striatal abnormalities. [provided by RefSeq, May 2017].