Genome Editing 2018 will explore functional genomics technologies for translational research and therapeutics
The conference will address applications of genome editing in a variety of biological systems, featuring:
- A high-impact, packed day of talks, discussions and several hours of networking
- Oral presentations on latest developments in the field of genome editing by an international faculty of leading researchers from academia and industry
- Update on CRISPR patent wars
- Ethical debate
- Trade exhibition
- Excellent networking opportunities, and a relaxed and friendly environment
Dr Annaleen Vermeulen from Horizon Discovery Group will be talking at Genome Editing on 'Using synthetic guide RNAs in CRISPR-mediated transcriptional activation to understand gene function'.
CRISPR activation (CRISPRa) is one of the most promising new technologies for gene overexpression, because genes are upregulated from their endogenous promoter and genomic context for more biologically relevant results. The development of CRISPRa technology and the use of synthetic guide RNAs in CRISPRa for robust gene transcriptional activation will be described for screening applications. Considerations for activation experimental design and applications in phenotypic assays will be shown.