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HaploDay 2016

Genetics in Haploid Cells

The unique genetics of haploid cells offer researchers a number of distinct advantages for studying genetic interactions, be it through genome wide loss of function screens or through CRISPR modified knockout or knockin cell lines. To better understand how this model system might be applied in biological research, Horizon Discovery organised the inaugural HaploDay 2016 – Genetics in Haploid Cells symposium.

Featuring an outstanding line up of speakers, and bringing together a wide cross section of researchers, the goal of Haploday was to accelerate the development of this nascent platform by sharing experience and fostering collaborations.

 

Program

9:00-9:15

Introduction and Welcome

Tilmann Buerckstuemmer, Horizon Discovery and Giulio Superti-Furga, CeMM

9:15-10:00

Keynote Lecture: Haploid screens to unravel disease networks

Thijn Brummelkamp, National Cancer Institute, Amsterdam

Forward Genetic Screening in Haploid Human Cells

10:00-10:30

Hunting critical host factors for viral infection

Jan Carette, Stanford University

10.45-11.15

Haploid screens identify HUSH - a novel epigenetic repressor complex

Paul Lehner, University of Cambridge

11.15-11.45

Solute carriers, metabolism and drug response: the magic triangle

Giulio Superti-Furga, CeMM, Research Center for Molecular Medicine

11.45-12:00

Drug potentiation CRISPR screens in haploid cells: looking for the missing needles in the haystack

Jon Moore, Horizon Discovery

12.00-12:15

A forward genetic approach to identify new modulators of Hedgehog signaling in haploid ES cells

Giulio di Minin, ETH Zurich

Haploid Murine Embryonic Stem Cells

13.00-13.30

Dissecting the exit from pluripotency using haploid ES cells

Martin Leeb, University of Vienna

13.30-14.00

An inducible and revertible embryonic stem cell biobank for functional genomics identifies novel players in angiogenesis

Ulrich Elling, IMBA, Institute of Molecular Biotechnology

Reverse Genetic Screens and Analyses

14:00-14.30

Parallel reverse genetic screening in mutant human cells using transcriptomics

Sebastian Nijman, University of Oxford

14.30-15.00

HAP1-knockout directed target gene discovery of genes regulated by KRAB-TRIM28 protein complexes

Hans-Jürgen Thiesen, University of Rostock

15.15-15.45

Landscape of rescue interactions across the Fanconi Anaemia DNA repair pathway

Georgia Velimezi, CeMM, Research Center for Molecular Medicine

15.45-16.15

Forward genetic screening in haploid cells: beyond CRISPR/Cas9

Josep Forment, University of Cambridge

16.15-16.30

Haploid chemical genomics reveals the crosstalk between bromodomain proteins BRD4 and TAF1

Sara Sdelci, CeMM, Research Center for Molecular Medicine

Human Stem Cells

16.30-17.00

Biallelic targeting in human stem cells at scale

Bill Skarnes, Wellcome Trust Sanger Institute

17.00-17.30

Haploid human embryonic stem cells

Nissim Benvenisty, Hebrew University of Jerusalem

 

In association with:

When

June - 09, 2016

Starting 12:00 AM - 12:00 AM

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Where

Vienna Austria

Medical University of Vienna

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