Genetics in Haploid Cells
The unique genetics of haploid cells offer researchers a number of distinct advantages for studying genetic interactions, be it through genome wide loss of function screens or through CRISPR modified knockout or knockin cell lines. To better understand how this model system might be applied in biological research, Horizon Discovery organised the inaugural HaploDay 2016 – Genetics in Haploid Cells symposium.
Featuring an outstanding line up of speakers, and bringing together a wide cross section of researchers, the goal of Haploday was to accelerate the development of this nascent platform by sharing experience and fostering collaborations.
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Program |
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9:00-9:15 |
Introduction and Welcome Tilmann Buerckstuemmer, Horizon Discovery and Giulio Superti-Furga, CeMM |
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9:15-10:00 |
Keynote Lecture: Haploid screens to unravel disease networks Thijn Brummelkamp, National Cancer Institute, Amsterdam |
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Forward Genetic Screening in Haploid Human Cells |
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10:00-10:30 |
Hunting critical host factors for viral infection Jan Carette, Stanford University |
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10.45-11.15 |
Haploid screens identify HUSH - a novel epigenetic repressor complex Paul Lehner, University of Cambridge |
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11.15-11.45 |
Solute carriers, metabolism and drug response: the magic triangle Giulio Superti-Furga, CeMM, Research Center for Molecular Medicine |
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11.45-12:00 |
Drug potentiation CRISPR screens in haploid cells: looking for the missing needles in the haystack Jon Moore, Horizon Discovery |
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12.00-12:15 |
A forward genetic approach to identify new modulators of Hedgehog signaling in haploid ES cells Giulio di Minin, ETH Zurich |
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Haploid Murine Embryonic Stem Cells |
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13.00-13.30 |
Dissecting the exit from pluripotency using haploid ES cells Martin Leeb, University of Vienna |
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13.30-14.00 |
An inducible and revertible embryonic stem cell biobank for functional genomics identifies novel players in angiogenesis Ulrich Elling, IMBA, Institute of Molecular Biotechnology |
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Reverse Genetic Screens and Analyses |
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14:00-14.30 |
Parallel reverse genetic screening in mutant human cells using transcriptomics Sebastian Nijman, University of Oxford |
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14.30-15.00 |
HAP1-knockout directed target gene discovery of genes regulated by KRAB-TRIM28 protein complexes Hans-Jürgen Thiesen, University of Rostock |
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15.15-15.45 |
Landscape of rescue interactions across the Fanconi Anaemia DNA repair pathway Georgia Velimezi, CeMM, Research Center for Molecular Medicine |
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15.45-16.15 |
Forward genetic screening in haploid cells: beyond CRISPR/Cas9 Josep Forment, University of Cambridge |
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16.15-16.30 |
Haploid chemical genomics reveals the crosstalk between bromodomain proteins BRD4 and TAF1 Sara Sdelci, CeMM, Research Center for Molecular Medicine |
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Human Stem Cells |
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16.30-17.00 |
Biallelic targeting in human stem cells at scale Bill Skarnes, Wellcome Trust Sanger Institute |
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17.00-17.30 |
Haploid human embryonic stem cells Nissim Benvenisty, Hebrew University of Jerusalem |
In association with: