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What is the siRNA performance guarantee?
The siGENOME and ON-TARGETplus SMARTpool siRNA reagents (including version 2.0), and at least 3 out of the 4 individual siRNAs are guaranteed to silence target gene expression by at least 75% at the mRNA level when used under optimal delivery conditions (confirmed using a validated positive control siRNA). Silencing should be monitored at the mRNA level 24 - 48 hours after transfection using 100 nM siRNA.
Note: Most siGENOME and ON-TARGETplus siRNA products are highly functional at 5-20nM working concentration.
Accell siRNA reagents (SMARTpool and three of four individual siRNAs in the set of 4) are guaranteed to silence target gene expression by at least 75% at the mRNA level when used under optimized conditions as defined here: https://horizondiscovery.com/en/blog/2018/guaranteed-silencing-with-accell-sirna-in-3-easy-steps