What is the siRNA performance guarantee?

The siGENOME and ON-TARGETplus SMARTpool siRNA reagents, and at least 3 out of the 4 individual siRNAs are guaranteed to silence target gene expression by at least 75% at the mRNA level when used under optimal delivery conditions (confirmed using a validated positive control siRNA). Silencing should be monitored at the mRNA level 24 - 48 hours after transfection using 100 nM siRNA.

Note: Most siGENOME and ON-TARGETplus siRNA products are highly functional at 5-20nM working concentration. 

Accell siRNA reagents (SMARTpool and three of four individual siRNAs in the set of 4) are guaranteed to silence target gene expression by at least 75% at the mRNA level when used under optimized conditions as defined here: https://horizondiscovery.com/en/blog/2018/guaranteed-silencing-with-accell-sirna-in-3-easy-steps