Lincode Non-targeting Control Pool is the ideal negative control for RNAi experiments for knockdown of human long, noncoding RNAs (lncRNAs). The four component Lincode Non-targeting siRNAs are designed to leverage seed-region optimization and proprietary dual-strand modification patterns to have fewer off-targets than traditionally designed negative control siRNAs. Changes in cells treated with these controls reflect a baseline cellular response that can be compared to the levels in cells treated with target-specific siRNA.
This control is identical to the ON-TARGETplus Non-targeting Control Pool (Cat# D-001810-10). It is also being sold under the Lincode name for ease of ordering by customers new to RNAi. Either catalog item is suitable for Lincode and ON-TARGETplus siRNA experiments.
Lincode siRNAs are modified with a proprietary dual-strand modification that improves siRNA functionality. Additionally, off-targets are reduced due to: