A validated positive silencing control targeting the Lamin A/C genes in human, mouse, and rat cell lines. Useful for determination of optimal RNAi experimental conditions.
siGENOME Lamin A/C Control siRNA is a validated positive control, guaranteed to silence Lamins A and C in human, mouse, or rat cells. siGENOME positive control siRNA designs are highly functional, chemically synthesized, and mostly unmodified siRNA duplexes that allow positive silencing for validation of experimental design and detection methodologies.
Lamins are intermediate filament-type proteins, which form major components of the nuclear lamina. Lamins A and C have close sequence homology and are derived by differential splicing and alternative polyadenylation from one gene. This gene is abundantly expressed in most cells and because it is non-essential, knockdown of the corresponding mRNA does not affect cell viability