Understand disease mechanisms at the genomic level
Gene modulation refers to the process of temporarily altering gene expression levels without making heritable changes to the underlying cellular DNA. The most common gene modulation techniques involve silencing gene function (knockdown) via RNAi or CRISPRi techniques, or increasing expression (activation/overexpression) via cDNA, ORF or CRISPRa techniques.
Horizon offers a wide selection of trusted reagents for both gene knockdown and activation.
RNAi solutions by Dharmacon™ make gene silencing simple, so you can focus on the functional result!
CRISPR activation, cDNA & ORF reagents for reliable gene expression solutions to suit any workflow.
Top 3 tips for RNAi experiment success
Suggestions from our team of PhD trained scientists for getting your RNAi experiments working successfully!
siRNA selection guide
A quick tool to help determine the ideal siRNA product line and format for your needs.
shRNA selection guide
Find the best shRNA product line and format for your next experiment.
Gene silencing workflow in difficult-to-transfect cell lines
An experimental workflow for gene silencing with self-delivering Accell™ siRNA.
siRNA pooling strategies explained
What factors should be considered when deciding between using an siRNA individual or pool?