Functional genomic screening

From target selection to patient stratification.
Identify and characterize therapeutic targets and biomarkers.

Arrayed genomic screening service

Get quality screening results, right the first time.

Using synthetic crRNA and siRNA reagents on a one-gene per well basis with complex assay readouts.

Pooled genomic screening service

Dedicated team for each pooled screening project.

Employing lentiviral CRISPRko/i/a approaches in highly multiplexed pooled screens.

Screening libraries

Have flexibility: Select from catalog CRISPR and RNAi libraries or create custom libraries in pooled and arrayed formats.

Ensuring library specificity with algorithm optimized guide RNA.

RNA-based immune cell screens

Gene editing service for primary human immune cells.

Address clinically relevant biological questions in vitro.

Webinar - CRISPR screening from target selection to patient stratification

Video - Gene modulation technologies in the development of cell based therapies

Learn about the principles, strategies and experimental outcomes of CRISPR screening     

App note: Dual CRISPRi/a screens

Read about CRISPR screens for:

  • Drug mechanisms of action
  • Target identification and validation

App note: Pooled phenotypic CRISPR screens

Read more about pooled CRISPR–Cas9 knock-out screens - valuable tools for new drug target identification

CRISPR knockout screening

Probe gene function. Find drug targets. Stratify patients.

Custom services available for unique research projects.

Single-cell CRISPR screening

Identify the genetic interactions that underlie a treatment response with pooled CRISPR screening followed by single cell analysis.

CRISPRa/i Screening

CRISPRa screening

CRISPR activation offers transient gain-of-function screening using endogenous expression mechanisms.

CRISPRi screening

CRISPR interference screening offers transient loss-of-function screening with the accuracy of the CRISPR guide system.

Dual CRISPRi/a screening

Exploit the power of paired loss-of-function and gain-of-function screening.

Use of parallel CRISPRi and CRISPRa gene modulation to identify drug interactions with paired gene perturbation analysis.

App note: Whole-genome CRISPRa screening

In this application note, we present a human whole-genome CRISPRa platform and demonstrate its effectiveness in identifying resistance genes complementary to those identified through loss-of-function screening. The ability to enhance transcription by several orders of magnitude offers researchers the opportunity to explore resistance mechanisms based on a CRISPRa-driven gain-of-function platform. 

siRNA screening

Benefit from rapid and efficient workflows.

Expanding your gene modulation options.

Functional genomic screening with CRISPR technologies

Learn about CRISPR screening and techniques

Review article

Read a recent insightful review article headlining in SLAS Discovery's March issue entitled 'CRISPR: A Screener's Guide'.

CRISPR screens in primary human T cells

Gain a better understanding of how immune cells function using functional genomic screens.

Podcast: CRISPR screens

Listen to the recent podcast hosted by GEN:

CRISPR Screens Speed Drug Discovery Efforts in Disease Intervention