Human Duet siRNA Library - Drug Targets
Duet siRNA Libraries are paired libraries of siGENOME and ON-TARGETplus siRNA SMARTpool reagents. The Human Duet Drug Targets library includes genes involved with apoptosis, senesence, nucleic acid binding, autophagy, DNA repair, and characterized nuclear receptors, along with other genes that are considered potential targets for therapeutics not already contained in other libraries.
Drug Targets may be ordered on its own or as one of nine subset libraries in the Druggable Genome siRNA Library (see Figure 1, Supporting Data tab).
Highlights
- Increase confidence in your RNAi screen with two guaranteed, highly functional SMARTpool siRNA reagents (see Figure 2, Supporting Data tab)
- Screen the libraries side-by-side to move high confidence hits through the pipeline faster (see Figure 3, Supporting Data tab)
- Use the libraries separately as a cost-effective way to obtain two guaranteed collections of highly potent siRNA reagents
siRNA Designs
Both siGENOME and ON-TARGETplus siRNA reagents utilize the same SMARTselection foundational elements for highly functional designs. ON-TARGETplus designs are additionally filtered for specificity-enhancing features that improve the potential for unique designs.
- In 30% of genes (across the human genome), all eight siRNA sequences targeting a single gene are unique.
- Only 5% of genes share four siRNA sequences across both product lines.
- Even in cases of identical designs, it has been widely demonstrated that ON-TARGETplus specificity-enhancing modifications provide distinct and reduced off-target signatures and thus can be treated as unique silencing reagents.
Gene Targets
For a complete list of target genes in this siRNA Library, please contact Technical Support.
