Zoonome Custom siRNA Libraries

On-demand custom siRNA screening libraries for any species. Ensure library specificity with algorithm-designed siRNA produced with a novel enzymatic method.

Supporting large functional genomics studies in non-human or mouse models. Screen 1000 gene targets or up to the whole genome, helping you find the right solution! All that's required is species information and a gene list to get a targeted siRNA library for your model organism.

Working with alternative species (dog, pig, rat, cow, mosquito, hamster, monkey, etc.)? Utilize a novel enzymatic method to generate large arrayed libraries of algorithm-designed siRNAs for any species with an annotated genome!*

Request pricing - Zoonome custom siRNA libraries »


  • Novel enzymatic process for generation of functional, 21 mer siRNA duplexes for arrayed knockdown studies
  • On-demand plated collections of pooled siRNAs (4 algorithm-designed siRNAs in a single well) for RNAi screening studies in non-human or mouse cells
  • Minimum 1000 genes up to whole genome collections for any organism with an annotated genome
  • Expert siRNA design from the SMART selection algorithm
  • Provided in 384-well plates (96-well upon request) for high-throughput studies

*Target species must have an annotated genome in either the RefSeq or Ensembl™ (Genome Research Limited) database for use as input to the SMARTselection siRNA design algorithm.

Learn more about Zoonome siRNA libraries and pricing, submit a price quote request and have a dedicated team member contact you. Due to their highly custom nature, all Zoonome libraries are sold by quote only.  Note that orders can take up to 12 weeks to fulfill, so don't delay and inquire today!

The following species have been pre-validated to have an annotated genome database in Ensembl™ (Genome Research Limited) or RefSeq that is suitable for generation of genome wide siRNA designs for creation of a Zoonome siRNA library.

Can't see species of interest on the list?

No problem. Just submit it, along with the other requested information on the Request pricing form, and we will determine feasibility for you.

Bonobo Pan paniscus
Cat Felis catus
Chimpanzee Pan troglodytes
Chinese Hamster Cricetulus griseus
Cow Bos taurus
Dog Canis familiaris
Dolphin Tursiops truncatus
Elephant Loxodonta africana
Ferret Mustela putorius furo
Goat Capra hircus
Golden Hamster Mesocricetus auratus
Gorilla Gorilla gorilla gorilla
Guinea Pig Cavia porcellus
Horse Equus caballus
Marmoset Callithrix jacchus
Megabat Pteropus vampyrus
Microbat Myotis lucifugus
Olive Baboon Papio anubis
Opossum Monodelphis domestica
Orangutan Pongo pymaeus abelii
Panda Ailuropoda melanoleuca
Pig Sus scrofa
Platypus Ornithorhynchus anatinus
Rabbit Oryctolagus cuniculus
Rat Rattus norvegicus
Rhesus Monkey Macaca mulatta
Rhinoceros Ceratotherium simum simum
Sheep Ovis aries
Sloth Choloepus hoffmanni
Squirrel Ictidomys tridecemlineatus
Wallaby Macropus eugenii
Chicken Gallus gallus
Duck Anas platyrhynchos
Turkey Meleagris gallopavo
Zebra Finch Taeniopygia guttata
Fugu Takifugu rubripes
Medaka Oryzias latipes
Nile Tilapia Oreochromis niloticus
Stickleback Gasterosteus aculeatus
Zebrafish Danio rerio
American Alligator Alligator mississippiensis
Chinese Alligator Alligator sinensis
Armyworm Spodoptera frugiperda
Fruitfly Drosophila melanogaster
Monarch Butterfly Danaus plexippus
Mosquito Aedes aegypti
Frog Xenopus tropicalis
Sea Squirt Ciona intestinalis
Purple Sea Urchin Strongylocentrotus purpuratus
Roundworm Caenorhabditis elegans
Yeast Saccharomyces cerevisiae
zoonome alternative methods 

Enzymatic methods for siRNA production involve more steps than chemical synthesis, but are less expensive overall and result in a smaller quantity that is appropriate for a single end-user. Zoonome siRNA libraries utilize novel enzymatic methods to generate on-demand arrayed siRNA libraries for model species where synthetic libraries are not available.

Functionality of Zoonome siRNA (z-siRNA) in CHO-K1 cells

z sirna functionality cho k1 cells 

Figure 1. CHO-K1 (Chinese hamster) cells were treated with z-siRNA pools targeting 16 genes and assessed for functional knockdown (upper graph) and cell viability (lower graph). All z-siRNA reagents achieved potent knockdown (>75%) while maintaining high cellular viability. Z-siRNAs at 25 nM were delivered with DharmaFECT 4, 0.5 ug per well and assayed 48 hr post-transfection.