Lincode siRNA Libraries
Ensure library specificity. Choose from collections of human or mouse siRNAs based on RefSeq lncRNA genes with NR_ Accession numbers.
Elucidate novel biological pathways and disease progression with unbiased RNAi screens. Provide a more complete picture of the genes involved in your phenotype of interest. Assess potential roles for microRNA and lncRNA, in addition to protein-coding genes.
Human and Mouse Lincode siRNA screening libraries are available as SMARTpool or a set of 4 individual siRNAs to support efforts to decipher lncRNA function.
- Patented dual-strand modification pattern on all siRNAs to reduce off-targets
- Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake
- Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity
- Available as SMARTpool siRNA reagents or a Set of 4 siRNAs in 96-well or 384-well plates
3430 total long noncoding RNA gene targets containing at least one NR accession number, includes siRNAs targeting NR transcripts within protein coding genes.
1997 total long noncoding RNA gene targets containing at least one NR accession number, includes siRNAs targeting NR transcripts within protein coding genes.
Lincode siRNA reagents available as plated libraries for any customer-defined collection of lncRNAs of interest.
Product Line Selection
Which siRNA is right for you?
Dharmacon offers four complete predesigned product lines across human, mouse and rat genomes. Use the table below to assist you in determining the right siRNA product line for your needs.
|Cost-effective, efficient silencing||High specificity for reduced off-targets + efficient silencing||Highly specific knockdown of long noncoding RNA (lncRNA)||Target silencing in difficult-to-transfect cells|
|siGENOME siRNA||ON‑TARGETplus siRNA||Lincode siRNA||Accell siRNA|
|Predesigned for Human, Mouse and Rat protein-coding genes||✔||✔||✔|
|Predesigned for Human and Mouse long noncoding RNA (lncRNA)||✔|
|Recommended for transfectable mammalian cells in culture||✔||✔||✔|
|Recommended for neuronal, suspension, primary and other difficult-to-transfect cells||✔|
|Recommended transfection reagent||DharmaFECT transfection reagent||DharmaFECT transfection reagent||DharmaFECT transfection reagent||None required|
|Available as SMARTpool reagent||✔||✔||✔||✔|
|Available as four individual siRNAs||✔||✔||✔||✔|
|Guaranteed knockdown by SMARTpool and 3 of 4 siRNAs||✔||✔|
|Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake||Selective application when thermodynamic analysis indicates it necessary for favorable antisense RISC loading||✔||✔||✔|
|Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity||✔||✔|
|Modifications to facilitate cellular uptake without separate transfection reagents||✔|
|Stabilizing modifications to prevent nuclease-mediated degradation||✔|
|Sequence information provided with purchase||✔||✔||✔||✔|