Lincode siRNA Libraries

Ensure library specificity. Choose from collections of human or mouse siRNAs based on RefSeq lncRNA genes with NR_ Accession numbers.

Elucidate novel biological pathways and disease progression with unbiased RNAi screens. Provide a more complete picture of the genes involved in your phenotype of interest. Assess potential roles for microRNA and lncRNA, in addition to protein-coding genes.

Human and Mouse Lincode siRNA screening libraries are available as SMARTpool or a set of 4 individual siRNAs to support efforts to decipher lncRNA function.

Highlights

  • Patented dual-strand modification pattern on all siRNAs to reduce off-targets
  • Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake
  • Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity
  • Available as SMARTpool siRNA reagents or a Set of 4 siRNAs in 96-well or 384-well plates
  • Human NR lncRNA Library

    3430 total long noncoding RNA gene targets containing at least one NR accession number, includes siRNAs targeting NR transcripts within protein coding genes.

  • Mouse NR lncRNA Library

    1997 total long noncoding RNA gene targets containing at least one NR accession number, includes siRNAs targeting NR transcripts within protein coding genes.

  • Cherry-pick libraries

    Lincode siRNA reagents available as plated libraries for any customer-defined collection of lncRNAs of interest.

Product Line Selection

Which siRNA is right for you?

Dharmacon offers four complete predesigned product lines across human, mouse and rat genomes. Use the table below to assist you in determining the right siRNA product line for your needs.

  Cost-effective, efficient silencing High specificity for reduced off-targets + efficient silencing Highly specific knockdown of long noncoding RNA (lncRNA) Target silencing in difficult-to-transfect cells
  siGENOME siRNA ON‑TARGETplus siRNA Lincode siRNA Accell siRNA
Predesigned for Human, Mouse and Rat protein-coding genes  
Predesigned for Human and Mouse long noncoding RNA (lncRNA)      
Recommended for transfectable mammalian cells in culture  
Recommended for neuronal, suspension, primary and other difficult-to-transfect cells      
Recommended transfection reagent DharmaFECT transfection reagent DharmaFECT transfection reagent DharmaFECT transfection reagent None required
Available as SMARTpool reagent
Available as four individual siRNAs
Guaranteed knockdown by SMARTpool and 3 of 4 siRNAs    
Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake Selective application when thermodynamic analysis indicates it necessary for favorable antisense RISC loading
Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity    
Modifications to facilitate cellular uptake without separate transfection reagents      
Stabilizing modifications to prevent nuclease-mediated degradation      
Sequence information provided with purchase