The CHO Cell Line – From Reliable Workhorse to State-of-the-art Protein Powerhouse
In this podcast, Alan Dickson, Ph.D., Professor of Biology at the Manchester Institute of Biotechnology, University of Manchester talks about the evolution of the CHO Cell line from isolation to workhorse of the biomanufacturing industry, to gene edited knockout variants. An explanation is given why CHO cells have been so successful and how this success continues to be improved upon for manufacture of emerging therapeutics. Professor Dickson discusses his group’s long trajectory in bioprocessing research, specifically the Chinese Hamster Ovary (CHO) cell line. Today CHO cells are the work horse for the development and manufacturing of biopharmaceutical products, but back in 1957 when Puck managed to isolate and keep in culture the first CHO-K1 cells, nobody could have anticipated this success.