Attribute Overview

Active
Best CI
Best CI Error
Best CI Level
Chemical ID
Chemical Name
Coalism Average
Coalism Average Error
Coalism Excess
Coalism Log Chi Squared
Coalism Model
Coalism Parameters
Coalism Volume
Coalism Volume Error
Combination Name
Datasource
Dose Matrix
Dose Matrix Coverage
Dose Matrix Data
Dose Matrix Error
Dose Matrix Error Volume
Dose Matrix Interpolated
Dose Response Analytical Output
  • Dose Response analytical output is created for each dose response item. A dose response item exists for each individual test substance and fixed ratio mixture present as a stand-alone item or as a constituent of a dose matrix item.
  • A dose response item is comprised of a series of dose response points arranged by increasing dose. Additional output is created for individual substance characteristics provided by the datasource associated with the dose response item. Additional output is not created for any dose response item that represents a fixed ratio mixture.
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Dose Response Chart
  • The Dose Response Chart value is a figure which represents the dose response item as a chart with two series. The first series is comprised of the individual dose response points, including response value and response error estimate, arranged by increasing dose. The second series is a continuous representation of the response of the sigmoid instance selected as the best fit for the dose response item.
  • Dose Response Chart
  • Variable type (units): Figure
  • Number of values: 1
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Dose Response Classification
Dose Response Data
  • The Dose Response Data value is a block of preformatted tab-delimited text comprising the individual dose response points, including response value and response error estimate, arranged by increasing dose. For more information see Dose Response Data in section Output Data Formats.
  • Variable type (units): Text
  • Number of values: 1
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EC50
  • The EC50 value is the dose that corresponds to 50% of the max parameter of the sigmoid instance selected as the best fit for the dose response item. The EC50 value is an estimate of the dose at which the substance(s) achieve one-half of the maximum achievable response.
  • EC50
  • Variable type (units): Numeric (uM)
  • Number of values: 1
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EC90
  • The EC90 value is the dose that corresponds to 90% of the max parameter of the sigmoid instance selected as the best fit for the dose response item. The EC50 value is an estimate of the dose at which the substance(s) achieve one-half of the maximum achievable response.
  • EC90
  • Variable type (units): Numeric (uM)
  • Number of values: 1
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Error Etimate - Fit
  • The fit error estimate is the derived standard error in the Max Response – Fit, found from the range in that parameter that corresponds to an insignificant change in chi-squared goodness-of-fit.
  • Error Estimate - Fit
  • Variable type (units): Numeric
  • Number of values: 1
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GI100
GI125
GI150
GI50
GI75
Greco Average
Greco Average Error
Greco Excess
Greco Log Chi Squared
Greco Model
Greco Parameters
Greco Volume
Greco Volume Error
Hit Score
IC50
  • The IC50 value is the dose from the sigmoid instance selected as the best fit for the dose response item that corresponds to response value of 0.5 for the Measure associated with the dose response item. For more information on Measure response values see Measures in section Analytical Methods. This value is undefined for dose response items not achieving a Max Response – a Requires a Fit value of at least 0.5.
  • IC50
  • Variable type (units): Numeric
  • Number of values: 0 or 1
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IC80
  • Variable type (units): Numeric
  • Number of values: 0 or 1
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IC90

Or ICSelect, IC50, GI50, GI175, GI100, GI125, GI150

  • The ICselect value is the dose from the sigmoid instance selected as the best fit for the dose response item that corresponds to the Measure response value specified by the user. For the Inhibition Measure, typical selections are 0.5 for an IC50, 0.9 for an IC90. For the Growth Inhibition Measure, useful values are 0.5 corresponding to the GI50, 1.0 corresponding to TGI (stasis), and 1.5 corresponding to the LC50 halfway between stasis and fully cidal. For more information on Measure response values see Measures in section Analytical Methods. This value is undefined for dose response items not achieving sufficient response – a fit value of at least the specified value.
  • IC Select
  • Variable type (units): Numeric
  • Number of values: 0 or 1
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Isobologram
  • The axis of the isobolograms are normalized from 0 to 1 in linear concentration units. The labeled uM concentration on each axis is the absolute concentration for each component alone, required to achieve the isobologram effect contour level.
  • The additivity line is the diagonal so, with both agents on a normalized axis, as you remove one effective dose you have to add back the other to stay on the diagonal.
  • Variable type (units): Numeric
  • Number of values: 1
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Max CI
Max Combo Effect
Max Dose Present
  • The Max Dose present value is the maximum dose present in the dose response item.
  • Max Dose - Present
  • Variable type (units): Numeric (uM)
  • Number of values: 1
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Max Response - Fit
  • The Max Response – Fit value is the max parameter of the sigmoid instance selected as the best fit for the dose response item. For more information see Dose Response Fitting in section Analytical Methods.
  • Max Response - Fit
  • Variable type (units): Numeric
  • Number of values: 1
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Max Response - Observed
  • The Max Response – Observed value is the maximum response present in the dose response item.
  • Max Response - Observed
  • Variable type (units): Numeric
  • Number of values: 1
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Max Response - Observed - Dose
  • The Max Response – Observed – Dose value is the dose at which the Max Response – Observed value is present in the dose response item.
  • Max Response - Observed - Dose
  • Variable type (units): Numeric
  • Number of values: 1
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Max Response - Observed Error
Minimum Concentration Reported
N
Next Sample Count
Next Sample Dilution Factor
Next Sample Start
Protocol
Replicate Number
Response Area
  • The "Response Area" attribute replaces all previously labeled "Response Area [xxx]" attributes as of the 2010 Q4 release of the Chalice Analysis Engine. The new attribute provides the end user with the ability to define the concentration range for the integration as part of the analysis options for each analytical request. In addition, the system administrator can modify the default values for the concentration range.
  • Response Area
  • The concentration range is defined in terms of a lower and upper bound, between which the area between the curve and the measure null effect level will be integrated. Integration is not positively gated. The lower and upper bounds may be specified in relative (ec,ic) or absolute (uM,nM) units, and may be defined using heterogeneous units. The default values as supplied by Horizon in customer deployments are as follows:
  • Lower Bound: ec10
  • Upper Bound: 1mM
  • The default value effectively identifies potent and active compounds, but removes the bias of starting screening concentration.
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Self Cross
Size
SPE Average
SPE Average Error
SPE Excess
SPE Log Chi Squared
SPE Model
SPE Parameters
SPE Volume
SPE Volume Error
Steepness
  • The Steepness value is the steepness parameter of the sigmoid instance selected as the best fit for the dose response item. For more information see Dose Response Fitting in section Analytical Methods.
  • Steepness
  • Variable type (units): Numeric
  • Number of values: 1
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Substance Id
  • The unique identifier of the substance associated with the dose response item. The unique identifier is a composite value if the dose response item represents a fixed ratio mixture.
  • Variable type (units): Text
  • Number of values: 1
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Substance Name
  • The name of the substance (i.e., drug, biologic compound, etc.) associated with the dose response item. The substance name is a composite value if the dose response item represents a fixed ratio mixture.
  • Variable type (units): Text
  • Number of values: 1
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Sum Average
Sum Average Error
Sum Excess
Sum Log Chi Squared
Sum Model
Sum Parameters
Sum Volume
Sum Volume Error
Synergy Score
Synergy Score Error
Synergy SNR
Title