Human ON-TARGETplus siRNA Library - Tyrosine Kinases
siRNA designed and modified for greater specificity
With the Human ON-TARGETplus Tyrosine Kinase siRNA Library, researchers can suppress the expression of receptor and non-receptor tyrosine kinases critical for the control of several cell processes, including cell cycle, shape, proliferation, and differentiation. Tyrosine kinases constitute a large family of evolutionarily conserved enzymes that activate and deactivate a number of different metabolic pathways by catalyzing the phosphorylation of specific tyrosine residues on key effector proteins. Tyrosine kinases are typically classified into membrane-bound or non-membrane-bound groups and are found in nearly every mammalian cell type.
Highlights
- Patented dual-strand ON-TARGETplus modification pattern on all siRNAs to reduce off-targets
- Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake
- Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity
- Available as SMARTpool siRNA reagents or a Set of 4 siRNAs in 96-well plates
- Guaranteed target gene knockdown (see Specifications tab)
Highlights
- Six ready-to-use 96-well plate sets provided for two triplicate screens
- Pre-plated, validated RNAi controls included
- No aliquoting necessary, just resuspend and add cells
- siRNA reagents provided in clear plates at 6.25 pmol per well (50 nM final screening concentration)
- Black or white clear-bottom plates available to support assays involving fluorescent or luminescent detection
Gene targets
For a complete list of target genes in this siRNA Library, please contact Scientific Support or your local Sales Representative.
