Mouse ON-TARGETplus siRNA Library - Cell Cycle Regulation
siRNA designed and modified for greater specificity
The Mouse ON-TARGETplus Cell Cycle Regulation siRNA Library includes siRNA reagents targeting genes whose functions are crucial for controlling cell division. Of particular importance to the progression of the cell cycle are the cyclin-dependent kinases, or CDKs. Other protein families known to regulate the cell cycle include the members of the CIP/KIP family and the INK4 family of cell cycle inhibitors, members of the retinoblastoma protein family, and DNA replication factors, such as the cell division cycle proteins (CDCs).
The ON-TARGETplus siRNA designs and modifications reduce off-target effects while maintaining high-silencing potency for high-confidence screening results.
Highlights
- Patented dual-strand ON-TARGETplus modification pattern on all siRNAs to reduce off-targets (see Supporting Data tab)
- Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake
- Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity
- Available as SMARTpool siRNA reagents or as a Set of 4 siRNAs in 96 well plates
- Guaranteed target gene knockdown (see Guarantee tab)
Gene Targets
For a complete list of target genes in this siRNA Library, please contact Scientific Support.
