siGLO Lamin A/C Control siRNA (Human)

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siGLO Lamin A/C Control siRNA (Human)

Correlate fluorescence uptake and silencing activity with a single control

A stable, fluorescent positive control suitable for RNAi experiments in human cells. Silences the human Lamin A/C gene and is labeled with Cy3.

siGLO Lamin A/C Control siRNA is a validated positive control, guaranteed to silence Lamin A/C in human cells. This control siRNA is chemically modified to significantly extend siRNA stability and fluorescence compared to conventional siRNAs similarly labeled with fluorophores.

Lamins are intermediate filament-type proteins, which form major components of the nuclear lamina. Lamins A and C have close sequence homology and are derived by differential splicing and alternative polyadenylation from one gene. This gene is abundantly expressed in most cells, and because it is non-essential, knockdown of the corresponding mRNA does not affect cell viability.

Highlights

Targets accession numbers: NM_005572, NM_170707, NM_170708 (Human)
Labeled with Cy3
Absorbance/Emission Max is 547/563 nm
A Cy3, Rhodamine or PE filter can be used
Significantly extended intensity of the fluorescence signal (7 days or longer)
Positive correlation of fluorescence with transfection efficiency and target gene silencing

For a complete list of target genes in this siRNA Library, please contact Scientific Support or your local Sales Representative.