HAP1 knockout cell lines

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HAP1 Parental Cell Lines available

OBSCN ( Human )

Entrez Gene 84033 entrezgene 84033
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obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Alias

ARHGEF30 | UNC89

The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].