Autophagy Pathway

Browse our ready-to-go cell models to find your ideal cell line for autophagy research.

Simply search for your gene of interest to see all available cell models.

Browse Our Cell Lines

Frequently requested autophagy pathway related genes

  • ATG5
  • ATG13
  • ATG16L1
  • SQSTM1
  • ATG7
  • ATG14
  • RB1CC1
  • ULK1
  • ATG12

Autophagy related diseases explored with gene edited cell lines

As demonstrated by the 2016 Nobel Prize winner, Yoshinori Ohsumi, autophagy is a fundamental process vital to cellular health. The molecular processes and signalling pathways controlling autophagy include numerous autophagy-related (Atg) genes, important stress-inducible intracellular protein, such as p62/A170/SQSTM1 and autophagosome localizing proteins such as LC3, among many others making this a complex network of control.

Autophagy Diagram

Gene deletion experiments in both mice and cell lines have implicated autophagy in the development of a number of diseases including; neurodegenerative diseases, cancer, infectious diseases, and metabolic diseases.

Furthermore, SNPs and mutations in genes encoding proteins involved in autophagy have been implicated in a wide variety of conditions including asthma, Crohn’s disease and cancers. 

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