Autophagy Pathway
Browse our ready-to-go cell models to find your ideal cell line for autophagy research.
Simply search for your gene of interest to see all available cell models.
Frequently requested autophagy pathway related genes
- ATG5
- ATG13
- ATG16L1
- SQSTM1
- ATG7
- ATG14
- RB1CC1
- ULK1
- ATG12
Autophagy related diseases explored with gene edited cell lines
As demonstrated by the 2016 Nobel Prize winner, Yoshinori Ohsumi, autophagy is a fundamental process vital to cellular health. The molecular processes and signalling pathways controlling autophagy include numerous autophagy-related (Atg) genes, important stress-inducible intracellular protein, such as p62/A170/SQSTM1 and autophagosome localizing proteins such as LC3, among many others making this a complex network of control.
Gene deletion experiments in both mice and cell lines have implicated autophagy in the development of a number of diseases including; neurodegenerative diseases, cancer, infectious diseases, and metabolic diseases.
Furthermore, SNPs and mutations in genes encoding proteins involved in autophagy have been implicated in a wide variety of conditions including asthma, Crohn’s disease and cancers.
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