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Autophagy Pathway

Autophagy related diseases explored with gene edited cell lines

As demonstrated by the 2016 Nobel Prize winner, Yoshinori Ohsumi, autophagy is a fundamental process vital to cellular health. The molecular processes and signalling pathways controlling autophagy include numerous autophagy-related (Atg) genes, important stress-inducible intracellular protein, such as p62/A170/SQSTM1 and autophagosome localizing proteins such as LC3, among many others making this a complex network of control.

Autophagy Diagram

Gene deletion experiments in both mice and cell lines have implicated autophagy in the development of a number of diseases including; neurodegenerative diseases, cancer, infectious diseases, and metabolic diseases.

Furthermore, SNPs and mutations in genes encoding proteins involved in autophagy have been implicated in a wide variety of conditions including asthma, Crohn’s disease and cancers.

Examples of popular knockout cell lines for autophagy pathway

ATG5 ATG13 ATG16L1
SQSTM1 ATG7 ATG14
RB1CC1 ULK1 ATG12

Browse our ready-to-go cell models to find your ideal cell line for autophagy research.

Simply choose a cell line background, then search for your gene of interest to view all available ready-to-go models.

Browse Our Cell Lines

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