Custom oligo synthesis
Dharmacon RNA and DNA synthesis
Flexible scale and purity to fit experimental needs and budget
Understanding functional genomics is critical to advance genetic research and therapeutic discovery. Dharmacon Reagents support researchers on this journey at the DNA, RNA, and protein level with the broadest range of functional genomic tools including industry leading gene modulation and gene editing solutions to help elucidate complex biological networks for functional genomic studies.
Known for almost 30 years as premier providers of synthetic oligonucleotides, Dharmacon Reagents were the first to offer algorithm designed synthetic siRNA for RNAi, and the first to offer guide RNA for CRISPR-Cas9 gene editing applications.
Dharmacon Reagents have you covered with a complete range of genomic solutions from single-gene experiments to whole genome screens facilitating advancements in genetic research and therapeutic discovery.
RNA interference
Dharmacon siRNA, shRNA, and ncRNA solutions
The most simple yet effective method for target gene knockdown in loss-of-function experiments
CRISPR gene editing
Dharmacon guide RNA, Cas9 nuclease, and knock-in reagents
Precisely edit any gene in any cell type at any scale
CRISPR modulation
Dharmacon guide RNA, dCas9-VPR, dCas9-SALL1-SDS3 nuclease and more for CRISPR modulation
Tools to promote (CRISPRa) or repress (CRISPRi) target gene transcription, without cutting the DNA.
Screening libraries
Dharmacon libraries offer flexibility and scale to fit your needs
Select from whole genome or gene family catalog CRISPR and RNAi libraries or create a custom library in pooled or arrayed format
30 years of Dharmacon reagent innovation
The first premier providers of synthetic RNA oligos...learn about our innovative journey
Your partner in research and discovery
Highest quality products for peace of mind
Our scientific support team is always available to help with choosing the right product and experimental support