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Add any of our CRISPR portfolio reagents (CRISPRko, CRISPRa, CRISPRi) to your cart to see reduced pricing effective in 2025

Dharmacon™ gene editing reagents provide the flexibility to achieve any edit, in any cell type, at any scale.
Our Dharmacon Edit-R™ line of predesigned CRISPR knockout guide RNAs offer guaranteed gene editing and are available as synthetic or expressed formats, in scales from individual reagents to genome wide libraries.
We also offer a user friendly custom CRISPR knockout guide design tool for use in 30+ species and with alternative nucleases, as well as design tools for HDR-mediated knock-in and site-specific editing experiments.

Dharmacon Edit-R CRISPR guide RNA

Guaranteed to edit the gene of interest
  • Predesigned, genome-wide designs for targeted knockout
  • Synthetic & expressed lentiviral guide RNA formats
  • Design tools for HDR knock-in, site-specific editing, and custom designs for 30+ organisms or alternative nucleases

Dharmacon Edit-R Cas9 nuclease

Cas9 solutions for vector-based or DNA-free CRISPR workflows
  • Protein & mRNA options for fast acting gene editing
  • Inducible and fluorescent lentiviral formats for user controlled expression and enrichment

CRISPR-Cas9 reagent format selection

Gene editing workflow guide

Planning a gene knockout or knock-in? This workflow guide will assist you in selecting the best Edit-R genome engineering tools for your application.

Dharmacon Edit-R guarantee

All predesigned Edit-R guide RNAs are fully guaranteed to edit the target gene of interest.

Dharmacon Edit-R CRISPR controls

Select proper controls to ensure your system is optimized for successful CRISPR experiments.

Dharmacon Edit-R knock-in templates

Synthetic single-strand DNA oligonucleotides or plasmid donor templates for precise genomic modification with the HDR pathway.