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RNAi Screening Libraries

Flexible, convenient and high-confidence screening results. Choose from our siRNA, shRNA and microRNA predesigned libraries. Small gene families to genome-wide collections.


  • Investigate the role of regulatory non-coding RNAs in your biological system
  • Accomplish multiplexed shRNA screening in vitro and in vivo
  • Perform siRNA screens without high throughput automation

siRNA Screening Libraries

  • Cherry-pick libraries

    Freedom with custom library design. Fast and easy online configuration and ordering of plated siRNA & microRNA reagents.

  • Human siRNA libraries

    Take advantage of predefined gene families, including druggable genes or whole genome.

  • Mouse siRNA libraries

    Utilize predefined siRNA libraries, including the most up-to-date whole mouse genome collection available.

  • RTF siRNA libraries

    Enable RNAi screening without the need for high-throughput automation using human and mouse SMARTpool siRNA libraries in a novel pre-dispensed format.

  • Lincode siRNA libraries

    Human or mouse siRNAs collections based on RefSeq lncRNA genes with NR_ Accession numbers.

shRNA Screening Libraries

microRNA Screening Libraries

  • Cherry-pick libraries

    Fast and easy online configuration and ordering of plated siRNA & microRNA reagents targeting your genes of interest.

  • miRIDIAN microRNA libraries

    Mimic and hairpin inhibitor libraries available for human, mouse, and rat microRNAs. Provided in 96-well plates for high-throughput phenotypic screening.

  • Pooled lentiviral screening libraries

    Investigate thousands of genes with a single transduction event with powerful multiplexed screening tools.

Custom Screening Libraries

  • Cherry-pick libraries

    Efficient online configuration and ordering of plated siRNA & microRNA reagents targeting your genes of interest.

  • Cherry-pick clone libraries

    Choose from our predesigned product lines of shRNA and over-expression reagents to build your own custom library.

Library discontinuation announcement - December 2020

Horizon will be discontinuing the sale of certain siRNA and shRNA catalog libraries, including all human siGENOME libraries, all Lincode siRNA libraries, all GIPZ, TRIPZ, and TRC gene family libraries, and all Decode pooled lentiviral shRNA libraries. Importantly, the sale and availability of individual gene reagents from these collections as well as Cherry-pick Custom Libraries will remain intact.

Find the complete list of discontinued libraries and recommended alternatives, here.

Bacterial glycerol stock

Bacterial culture transformed with a plasmid vector, grown in the presence of glycerol for freezer stock.


A mixture of four siRNAs provided as a single reagent. siGENOME and ON-TARGETplus SMARTpool reagents are guaranteed* to silence by 75% or better.

Set of four

Four unique siRNAs targeting a single gene provided as individual reagents. Three of four siGENOME and ON-TARGETplus siRNAs are guaranteed* to silence by 75% or better.

Pooled high-titer Lentiviral particles

Transduction-ready high-titer Lentiviral particle format.

Gene families and pathways:

Predefined libraries arranged by gene family and/or function.

Arrayed plates

Arrayed in 96-well or 384-well microtiter plates.


*siGENOME and ON-TARGETplus siRNA reagents (SMARTpool and at least three of four individual siRNAs) are guaranteed to silence target gene expression by at least 75% at the mRNA level when used under optimal delivery conditions (confirmed using validated positive and negative control siRNAs). Silencing should be monitored at the mRNA level 24-48 hours after transfection using 100nM siRNA.

Which RNAi screening library suits your experimental needs?

Use the table below to assist you in determining the right RNAi screening library for your needs.

Predefined siRNA libraries Predefined shRNA libraries Reverse Transfection Format (RTF) siRNA libraries SMARTvector Lentiviral shRNA libraries Decode Pooled Lentiviral shRNA libraries miRIDIAN Mimic and Hairpin Inhibitor libraries
Species Human, Mouse Human, Mouse Human, Mouse Human, Mouse, Rat Human Human, Mouse, Rat
Available as genome-scale collections
Available as custom library
Formats Gene families Arrayed plates SMARTpool Set of four Gene families Arrayed plates Glycerol Stock Gene families Arrayed plates SMARTpool Gene families Lentiviral particles Lentiviral particles Arrayed plates