The Prostate Cancer Panel cfDNA Reference Standard Negative Control is a well characterized, cell line-derived control material manufactured under ISO:13485 that includes 9 clinically relevant genes that are confirmed negative for 17 variants, except CNV in AR gene. This exciting new Multigene Multiplex product allows labs to perform fast, more reliable, and cost-effective validation of prostate cancer sequencing assays - saving the user time and money to achieve their quality assurance goals faster and allowing the user to assess the performance of cfDNA assays.
Genes covered: TP53, AR, PIK3CA, RB1, CDKN2A, STK11, PTEN, BRCA1, BRCA2
Cosmics: See table below
Allelic frequencies: 0% (AR gene CNV = 1)
Buffer: Tris-EDTA (10mM Tris-HCl, 1mM EDTA), pH 8.0
Fragment size: 160 bp
Unit size: 350 ng per vial
Concentration: 20 ng/µl
|Gene||COSMIC ID (v97)||DNA sequence change||Amino acid change||Expected allelic frequency (%)|
† No COSMIC ID available (variant detected in NGS data), genomic coordinates: SKT11, GRCh38, chr19:1220438
**Since the negative control has 1 copy of AR gene, the final copy number may vary if this panel is used to dilute the positive control panel (HD836).
Expiration: See all product shelf life information
Fragmentation size: D1000 DNA ScreenTape assay
Allelic frequency: Droplet Digital™ PCR
Quantification: Qubit® dsDNA BR assay (Invitrogen)
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