Cell Lines For Studying Phosphoinositide Function

Over 7,500 Ready-to-go cell models

Choose the cell model most relevant for your application from our Ready-to-go cell lines 

Browse cell models 

Express and Custom engineering services 

Supporting your specific application needs

Find out more 

Popular genes for phosphoinositide function studies

To enable better understanding of the role of phosphoinositides in basic cell and disease biology Horizon has knocked out a number of key genes involved in phosphoinositide metabolism that are expressed in HAP1 cells and non-essential. 

ARF1

MTMR14

PIK3R1

PIP5K1C

FIG4

MTMR3

PIK3R2

PITPNB

INPP5E

MTMR4

PIK3R3

SYNJ1

INPP5J

MTMR6

PIK3R6

SYNJ2

INPP5K

MTMR7

PIKFYVE

VAC14

INPPL1

OCRL

PIP4K2A

 

MTM1

PI4K2A

PIP4K2B

 

MTMR1

PI4K2B

PIP5K1A

 

 

Phosphatidylinositol and Phosphoinositides are a minor component of plasma and intracellular membranes. Lipid phosphatases and kinases can target the inositol group at the level of the hydroxyls situated in the positions 3, 4, and 5 generating a total of 7 phosphoinositides.

Many of these molecules have been identified as essential mediators of signal transduction in various cellular processes, even some of those initially thought to be simple intermediates. Deregulated phosphoinositide metabolism is linked to various human diseases and cancer.

Further research is necessary to elucidate the mechanism of action of phosphoinositides and the proteins involved in their metabolism in the wide range of cellular processes and compartments were they have been found.

Pathways Phosphoinositide