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Cell Lines For Studying Phosphoinositide Function

Cell lines for studying Phosphoinositide Function

To enable better understanding of the role of phosphoinositides in basic cell and disease biology Horizon has knocked out a number of key genes involved in phosphoinositide metabolism that are expressed in HAP1 cells and non-essential.

Phosphatidylinositol and Phosphoinositides are a minor component of plasma and intracellular membranes. Lipid phosphatases and kinases can target the inositol group at the level of the hydroxyls situated in the positions 3, 4, and 5 generating a total of 7 phosphoinositides.

Many of these molecules have been identified as essential mediators of signal transduction in various cellular processes, even some of those initially thought to be simple intermediates. Deregulated phosphoinositide metabolism is linked to various human diseases and cancer.

Further research is necessary to elucidate the mechanism of action of phosphoinositides and the proteins involved in their metabolism in the wide range of cellular processes and compartments were they have been found.

Pathways Phosphoinositide

Examples of popular knockout cell lines for studying Phosphoinositide Function

ARF1 MTMR14 PIK3R1 PIP5K1C
FIG4 MTMR3 PIK3R2 PITPNB
INPP5E MTMR4 PIK3R3 SYNJ1
INPP5J MTMR6 PIK3R6 SYNJ2
INPP5K MTMR7 PIKFYVE VAC14
INPPL1 OCRL PIP4K2A  
MTM1 PI4K2A PIP4K2B  
MTMR1 PI4K2B PIP5K1A  

Browse our ready-to-go cell models to find your ideal cell line for Phosphoinositide Function research.

Simply choose a cell line background, then search for your gene of interest to view all available ready-to-go models.

Browse Our Cell Lines

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