Cell Lines For Studying Sumoylation

SUMOylation is a reversible post-translational modification involved in transcription, DNA repair, chromatin remodeling, splicing, assembly of ribosomes and many other cellular processes. SUMO (small ubiquitin-like modifier) is attached as a monomer or polymer through a process akin to that of ubiquitination. It is attached via the sequential action of E1, E2 and E3 enzymes, and can be removed by SUMO1/Sentrin-specific proteases SENPs).

Pathways sumoylation trans

To support your research on the role and mechanism of SUMO modifications, Horizon has developed a collection of human knockout HAP1 cell lines that lack components of the SUMOylation pathway. These knockouts enable study of pathway redundancy, identification of subcellular function and characterization of the proteins themselves by providing a clean background in which mutants can be expressed.

Ready-to-go cell models 

Find the cell model relevant for your research quickly and easily. 

Simply search for a gene and choose Ready-to-go cell lines. 

Search for a gene

Examples of knockout cell lines

ARHGAP31

PIAS1

SENP1

SENP2

SENP3

SENP5

SUMO1

SUMO3