OncoSpan

Have confidence in your cancer assay

Optimize your validation or monitor assay performance with OncoSpan

Take advantage of a renewable, reproducible, and highly characterized reference control material providing consistency from assay development to routine monitoring.

• Highly multiplexed reference control panel containing over 370 variants across 152 oncogenes, including >27 indels
• Cell line derived control material is commutable to patient samples
• Develop, troubleshoot and assess bioinformatics performance with a companion high coverage, batch specific in silico NGS data set
• Available as cell-free DNA, FFPE curls, and genomic DNA
• Range of allele frequencies enable rapid determination of LOD in your assay and sensitivities
• Demonstrated repeatability and reproducibility with an R2 correlation coefficient in NGS ranging from 0.95 to 0.97 for all OncoSpan formats

OncoSpan applications

• Enable novel cancer assay development
• Conduct routine monitoring of assay performance and data analysis

Utilize NGS controls to calibrate your assays

• Improve patient selection for clinical trials
• Develop early cancer detection methods
• Assess therapeutic efficacy

OncoSpan publications

Read these research articles citing the use of OncoSpan reference standards.

• Validation of a pan-cancer targeted next generation sequencing panel in New Zealand | New Zealand Journal of Medical Laboratory Science
• Enabling variant calling in challenging FFPE samples by coupling a novel library preparation chemistry with exome sequencing | Journal of Clinical Oncology
• Moving towards a local testing solution for undetermined thyroid fine-needle aspirates: validation of a novel custom DNA-based NGS panel | Journal of Clinical Pathology
• Performance Analysis of Three Bioinformatic Variant Callers Using a Somatic Reference Standard | Children's Mercy Kansas City