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- Mimix™ Lymphoid Cancer Panel FFPE Reference Standard
Mimix™ Lymphoid Cancer Panel FFPE Reference Standard
Due to inherent genetic variability (somatic mutations) in lymphomas, precise diagnosis and prognosis depend heavily on molecular and genetic profiling. Specific mutations like SOCS1/CDKN2A for DLBCL and EZH2 for follicular lymphomas aid diagnosis and risk assessment. To support such precision testing, our engineered cancer cell lines mimic patient samples, offering a robust reference panel with clinically relevant mutations detectable in FFPE format. This ISO 13485 validated panel empowers the development of accurate companion diagnostics for improved lymphoma management.
Technical Product Information
Format: FFPE
Fixation method: 4% PFA (w/v)
Section size: 15µm
Cell density: 3 x 108 cells per block. Approx. 3.5 x 105 cells per section
Expected DNA yield: > 400 ng using Promega Maxwell RSC Plus Extraction kit
Genes covered: BRAF, CXCR4, DNMT3A, EZH2, IDH2, MYD88, NRAS, STAT3, TET2, TP53
Allelic frequencies: 6.00 - 14.00%
Verified mutations:
Gene | DNA sequence change | Amino acid change | Expected frequency (%) |
---|---|---|---|
BRAF | c.1799T>A | p. V600E | 10.00 |
CXCR4 | c.1012C>T | p.R338* | 8.00 |
DNMT3A | c.2644C>T | p. R882C | 10.00 |
EZH2 | c.1937A>G | p. Y646C | 10.00 |
IDH2 | c.514A>G | p. R172G | 10.00 |
MYD88 | c.818T>C | p.L273P | 10.00 |
STAT3 | c.1981G>T | p. D661Y | 6.00 |
TET2 | c.679del | p. E227fs | 9.00 |
NRAS | c.181C>A | p. Q61K | 10.00 |
TP53 | c.586C>T | p. R196* | 14.00 |
General information
Storage: 4°C
Shipping: Ambient
Expiration: See all product shelf life information
Intended use: For assay developers, molecular diagnostic labs (Research use only)
Quality control
Allelic frequency: Droplet Digital™ PCR
Quantification: Quantifluor
DNA Integrity: Agarose gel electrophoresis
Manufacturing Quality: ISO 9001:2015 and ISO 13485:2016
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