Mimix™ Myeloid Cancer Panel, cfDNA Reference Standard

The popular myeloid cancer panel is now available in cell-free DNA to support validation of liquid biopsy-based MRD assays

Product name change
As part of the continuous evolution of our portfolio, we have changed the name of our range to Mimix™ reference standards to better reflect the patient-like performance they provide.

While our product range has a new name, everything you rely on remains the same:

Identical formulation and performance
Same part numbers and SKUs
Existing protocols and procedures
Same technical specifications
Quality and reliability you trust

No action is required from you. Future orders, product labels, documentation, and communications will reference the new product name.

The Myeloid Cancer Panel cfDNA reference standard is a well-characterized cell line-derived control which contains 15 clinically-relevant variants across 14 genes. This cell-free DNA reference material allows labs to perform reliable and cost-effective validations of myeloid cancer liquid biopsy assays. QC pipelines are supported by controls manufactured under ISO:13485 with low allele frequencies, designed specifically to replicate cell-free patient samples in minimal residual disease (MRD) and liquid biopsy assays.

Technical data

Format: cfDNA

Genes covered: ABL1, ASXL1, CBL, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, NPM1, NRAS, SF3B1, TET2, TP53

Allelic frequencies: 0.50% - 1.00%

Buffer: Tris-EDTA (10mM Tris-HCl, 1mM EDTA), pH 8.0

Product information

Fragment size: 160 bp

Unit size: 350 ng per vial

Concentration: 20 ng/µl

Verified mutations:

Gene	DNA sequence change	Amino acid change	Expected allelic frequency (%)
ABL1	c.1001C>T	p.T315I	0.50
ASXL1	c.2388G>T	p.W796C	0.50
CBL	c.1208C>T	p.S403F	0.50
DNMT3A	c.2644C>T	p.R882C	0.50
EZH2	c.1253G>A	p.R418Q	0.50
FLT3	c.253G>T	p.D835Y	0.50
IDH1	c.394C>T	p.R132C	0.50
IDH2	c.515G>A	p.R172K	0.50
JAK2	c.1611_1616del	p.F537-K539>L	0.50
JAK2	c.1849G>T	p.V617F	0.50
NPM1	c.860_863dup	p.W288Cfs*12	0.50
NRAS	c.182A>T	p.Q61L	1.00
SF3B1	c.2219G>T	p.G740E	0.50
TET2	c.3782G>A	p.R1261H	0.50
TP53	c.722C>T	p.S241F	0.50

General information

Storage: 4°C

Expiration: See all product shelf life information

Quality control

Fragmentation size: D1000 DNA ScreenTape assay

Allelic frequency: Droplet Digital™ PCR

Quantification: Qubit® dsDNA BR assay (Invitrogen)

Intended use: For assay developers and molecular diagnostic labs for routine performance monitoring of molecular biology assays. Research use only. Not for diagnostic procedures.