Studying bromodomain containing proteins with a knockout cell line

Commonly used genes for BRD research

ASH1L

BRD4

EP300

TAF1L

ATAD2

BRD7

KAT2A

TRIM24

ATAD2B

BRD8

KAT2B

TRIM66

BAZ1A

BRD9

KMT2A

ZMYND11

BAZ1B

BRDT

PHIP

ZMYND8

BAZ2A

BRPF3

SMARCA2

 

BPTF

BRWD1

SP100

 

BRD1

BRWD3

SP110

 

BRD2

CECR2

SP140

 

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Using knockout models for bromodomain research projects

A number of proteins that use bromodomain (BRDs) for their recruitment to specific regulatory complexes have been implicated in the development of cancer.  Alongside this, gene re-arrangements and overexpression of BRD containing genes have also been reported in a number of cancers.

BRDs are also attractive targets for neurological and inflammatory diseases - potent and selective inhibitors to the BET (bromodomain and extraterminal domain) family are being trialled.

The human genome encodes 42 bromodomain-containing genes, which harbour 52 bromodomains (some genes contain more than one bromodomain).

Bromodomain Diagram

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