A number of proteins that use bromodomain (BRDs) for their recruitment to specific regulatory complexes have been implicated in the development of cancer. Alongside this, gene re-arrangements and overexpression of BRD containing genes have also been reported in a number of cancers.
BRDs are also attractive targets for neurological and inflammatory diseases - potent and selective inhibitors to the BET (bromodomain and extraterminal domain) family are being trialled.
The human genome encodes 42 bromodomain-containing genes, which harbour 52 bromodomains (some genes contain more than one bromodomain).
Examples of popular knockout cell lines for bromodomain
| ASh2L | BRD4 | EP300 | TAF1L |
| ATAD2 | BRD7 | KAT2A | TRIM24 |
| ATAD2B | BRD8 | KAT2B | TRIM66 |
| BAZ1A | BRD9 | KMT2A | ZMYND11 |
| BAZ1B | BRDT | PHIP | ZMYND8 |
| BAZ2A | BRPF3 | SMARCA2 |
|
| BPTF | BRWD1 | SP100 |
|
| BRD1 | BRWD3 | SP110 |
|
| BRD2 | CECR2 | SP140 |
|
Browse our ready-to-go cell models to find your ideal cell line for bromodomain research.
Simply choose a cell line background, then search for your gene of interest to view all available ready-to-go models.
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