Multiplexed base editing in sensitive cell types

Discover how base editing can enable your multiplex editing research in sensitive cell types.

Base editing is a next generation genome engineering tool that introduces single base changes that can be designed to generate a variety of cellular phenotypes including knockouts and disease models. Base editing is different from traditional CRISPR-Cas9 genome editing in that generation of double strand DNA breaks are avoided, resulting in healthier cells and reducing the risk of introducing unintended genomic aberrations.

In this application note, learn how Revvity’s Pin-point™ base editing platform was used to introduce multiple single base changes in one transfection in sensitive cell types like induced pluripotent stem cells and primary T cells. 

Up to four edits were introduced simultaneously to generate complex cell products without compromising efficiency, cell health, or genome integrity.

Save time and cost on your next complex engineering project with the Pin-point base editing platform and Revvity’s synthetic mRNA and sgRNA base editing reagents.


base editing in sensitive cells - app note imageRead our application note to learn more about Complex genome engineering with the Pin-point base editing system, even in sensitive cell types.


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Pin-point base editing platform

Novel three-part design and strong safety profile

Pin-point reagents

Three-component system featuring a nickase Cas9