miRIDIAN microRNA Mimic
Up-regulate endogenous microRNA activity for gain-of-function studies
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miRIDIAN microRNA Mimics are double-stranded RNA oligonucleotides designed to mimic the function of endogenous, mature microRNAs. miRIDIAN Mimics are chemically enhanced with the ON-TARGET modification pattern to preferrentially program RISC with the active microRNA strand. Predesigned mimics are available for all human, mouse, and rat microRNAs in the miRBase Database release 21.0.
Highlights
- Superior performance in comparison to native, double-stranded microRNA (see Figure 1, Supporting Data)
- Highly effective mimic of endogenous mature microRNA function (see Figure 2, Supporting Data)
- Preferential programming of RISC with active strand of microRNA
- Exclusion of passenger strand through proprietary chemical modification pattern
Applications
- Supplement microRNA activity to study gain-of-function effects
- Screen for microRNAs that regulate gene expression and affect cellular pathways
- Elucidate microRNA involvement in normal biological and disease pathways
- Identify and validate microRNA targets
miRIDIAN microRNA Mimics perform better than native double-stranded microRNA

Figure 1. | miRNA mimic function was assayed in HeLa cells 24 and 48 hours after transfection of 10 nM miR-375 native double-stranded mimic, native double-stranded mimic with modifications, or the miRIDIAN microRNA Mimic using a dual luciferase reporter system and normalized to the control (no mimic).
miRIDIAN microRNA Mimics simulate endogenous mature miRNA function

Figure 2. | miRIDIAN microRNA Mimic function for 11 human miRNAs was assayed in HeLa and HepG2 cells 48 hours after transfection of 10 nM mimic using a dual luciferase reporter system and normalized to the control (no mimic treatment). Similar results were obtained with 1 nM miRIDIAN microRNA Mimic (results not shown).