T-cell receptors (TCRs) are crucial components of T cell immunity, enabling the detection and subsequent elimination of abnormal, cancerous and infected cells. Dysfunctional T cell receptor signaling can lead to various immune deficiency or autoimmune diseases. In cancer treatment the study and modification of T cell receptor signaling is important for CAR-T cell therapy as well as modulation of the tumor microenvironment (TME). Modulating T cell activation can be important to avoid rejection of organ or stem cell transplants by the immune response.
19 result(s)
Revvity molecular reference standards are available for both germline and somatic variants. In this article we cover why this distinction is important, and what it means for the allele frequencies of variants in these two types of controls.
On Wednesday October 19, The Medical Device Innovation Consortium (MDIC) announced its partnership with Horizon Discovery to develop and manufacture somatic reference samples (SRSs) to simplify and support the validation of NGS-based cancer diagnostics.
In this blog, we take a look at ClaretBio’s app note on using Horizon’s cfDNA reference standards in the development of their novel sample prep kit.
Learn how to examine your NGS data to investigate false positives and negatives, and potential downstream applications
Now Horizon's popular reference standards have been exome sequenced for higher confidence and expanded applications. Read on to find out how this new level of product information will support your diagnostics pipeline.
Horizon's new Cell free DNA formulated in synthetic matrix reference offers greater compatibility with commonly used cfDNA extraction kits.
Key steps to successfully test, and monitor patients by liquid biopsy as an alternative to solid tumor.
Quality control (QC) is vital for Next-generation sequencing (NGS). Here we discuss best practices that will save you time, money, and headaches.
Isolation of genomic DNA from formalin fixed paraffin embedded (FFPE) tissues is a critical step for molecular diagnostic (MDx) assays. Here we investigate extraction of DNA from FFPE using five comparable methods.