OncoReference Data Set

Activity profiles of oncology focused standard-of-care drugs, emerging therapeutics, and targeted probes across 150 cell lines

OncoReference Data Set allows you to easily access single agent activity profiles of 200 oncology focused compounds screened across a panel of 150 cancer cell lines from 19 different indications.

Use The OncoReference Data Set to:

Compare the activity of your molecules to standard-of-care drugs and emerging therapeutics
Find responder and non-responder cell lines for your compound class
Select the right cell lines for your experiments

Compounds cover a wide range of mechanistic classes including apoptosis inducers, kinase inhibitors, DNA damage inducers and chromatin modulators.

OncoReference Data Set includes

Activity Profiles: Single agent activity profiles of 200 oncology focused compounds
Cell Lines: 150 clinically relevant cancer cell lines from 19 indications
Dose Response Format: 10-point, 3-fold dilution series
Treatment Time: 72 hours
Readout: Growth Inhibition and Inhibition as measured by cell proliferation (ATP endpoint). Growth Inhibition readout allows for differentiation of cytostatic and cytotoxic response of compounds

You will receive

Dose response curves
IC50, GI50, EC50
Maximum response and more
Access to Chalice™ Viewer bioinformatics software

Compounds include cell line collection

Apoptosis Inducers
PI3K/mTOR/Akt Inhibitors
Proteosome Inhibitors
DNA Damage Response Agents
DNA Damage Inducers
Cell Cycle Inhibitors
Cytoskeletal Inhibitors
MAP Kinase Family Inhibitors
Protein Tyrosine Kinase Inhibitors
Chromatin Modulators
And more…