On the Horizon

Leading news, knowledge, and industry trends in genetic research

Gene editing

40 result(s)

After all the hard work of editing your cell line, you want to have confidence in your new research model. So, how do you verify your cell line is what you expect it to be? Could a heterogeneous cell population be obscuring your editing effects? Is observed phenotype being caused by the targeted gene edit, or unintended off-target effects? Here we discus ways to add supporting data to validate your gene-engineering projects.

Cancer fusion genes are hybrid genes that produce abnormal proteins believed to catalyze further cancer growth and increase invasiveness. Here we highlight novel research using CRISPR gene editing to specifically target cancer fusion genes, which could offer many potential therapeutic applications.

The cellular DNA damage response (DDR) is an essential safeguard against cancer. Upon activation, the DDR can limit tumor progression at the early stages by inducing senescence or cell death. When this defense fails tumors are able to develop. However, with time, tumors accumulate more mutations in DNA repair proteins as cancers progress. The efficiency of DDR plays an essential role in the effectivity of cytotoxic treatments. Currently much research is focused on identifying the DDR mechanisms involved in cancers and how these dysfunctional processes can be utilized against tumor growth.