Ready-to-go cell models for epigenetics

Browse our ready-to-go cell knockout models to find your ideal cell line for autophagy research. 

Simply search for your gene of interest to see all available cell models.

Browse Our Cell Lines

Frequently requested epigenetics gene knockouts

ARHGEF1 BRWD3 KAT2A PHIP SUV39H1
ARID1B CBX1
KAT2B
PRMT3 TET1
ASH1L CECR2
KDM1A
RING1
TET2
ATAD2 DNMT1
KDM2B
SCFD2
TRDMT1
BAP1 EHMT1
KDM4D
SIRT5
TRIM66
BAZ1B EHMT2
KDM5C
SIRT6

WHSC1

BMI1 EZH1
KLF4
SIRT7
ZMYM3
BRD1 H3F3A
MBD1
SMARCA2
ZMYND8
BRD4 HDAC1
MBD3
SMARCC1
BRD8 HDAC2
MECP2
SMARCD3
BRDT HELLS
NSD1
SP1
BRPF3 JARID2
PBRM1
SP3

Epigenetic Marks (Markers)

The most important epigenetic marks include DNA methylation, histone methylation and histone acetylation.

All of these are reversible, i.e. the cell harbours a repertoire of enzymes that add or remove such marks to a specific genomic locus.

Enzymes that add marks are referred to as epigenetic writers (e.g. DNA methyl transferases or histone acetyl transferases) and those that remove marks are known as epigenetic erasers (e.g. histone demethylases or histone deacetylases).

Epigenetic Modification

Epigenetic marks are read-out by a specific subset of proteins referred to epigenetic readers (e.g. bromodomain-containing genes). Some examples of epigenetic mechanisms include; maternal effects, X-chromosome inactivation and imprinting amongst many others.

Epigenetic Diagram 2