Want to optimize RNAi experiments in difficult-to-transfect cell lines? Read our workflow recommendations for optimal delivery and functional silencing with Accell siRNA.
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Large-scale gain-of-function screens have not yet shown the same popularity as loss-of function experiments, mainly due to logistical complications of using the traditional reagents (ORFs). Here we explain the hurdles to setting up a high-throughput ORF screen, and how CRISPRa offers a new solution that can expand the screening toolbox to maximize your window of discovery.
Learn how to use our siDESIGN center for isoform or gene variant-specific siRNAs
Gene modulation is now more flexible and accessible thanks to Horizon's new CRISPRmod CRISPRi portfolio. The system leverages an inactive Cas9 complex to block transcription resulting in precision targeted gene down regulation. Read more about our newest offering:
A roundtable discussion with several of the women scientists at Horizon Discovery's Boulder office sharing personal reflections after Jennifer Doudna along with Emmanuelle Charpentier won the Nobel Prize in Chemistry this year.
Examples of studies using siRNAs targeting lncRNAs to inspire your next experiment.
Are you new to RNAi experiments and need some guidance on troubleshooting?
Tips and tricks for RNAi success - make sure to include necessary controls in your transfections!
Choosing the right cell-based screen from the plethora of options available can quickly become a complicated decision process. Here, we review two of the major options: cell panel and functional genomic screening.
The only self-delivering siRNA for difficult-to-transfect cells carries a functional guarantee.