Single-cell CRISPR screens
- Perform high-throughput screens
- Generate ultra-rich whole-transcriptome readouts per perturbation
- Distinguish cell subpopulation gene responses to perturbation
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CRISPR screening followed by single-cell analysis (CRISPRsc) provides critical gene information on how cellular subpopulations will respond to any treatment.
CRISPRsc enables an unbiased examination of critical genes involved in a phenotypic outcome within a heterogenous cell population, such as a tumor or group of cells at different temporal points in a pathway. This supports greater understanding of differences in cellular responses and subpopulation structure.
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