Functional genomic screens enable modulation of hundreds or thousands of genes in a single experiment to identify genetic pathways, cellular processes, novel therapeutic targets, and to genetically profile existing or potential therapeutics. This information can be used to support cell line development, elucidate mechanisms of action, facilitate patient stratification or explore new treatment paradigms.
With integrated solutions for CRISPR knockout, CRISPR activation, CRISPR inhibition, and RNAi technologies our screening portfolio provides you a complete functional genomic screening platform. Using either cell lines or primary cell cultures, Horizon’s screening platform can perform pooled, arrayed and even single cell screens with our flexible library technologies and formats. Libraries can be used either alone, or in tandem, and coupled with a variety of assay readouts.
Using synthetic CRISPR and siRNA reagents on a one-gene per well basis with complex assay readouts.
Employing lentiviral CRISPRko/i/a approaches in highly multiplexed pooled screens.
CRISPR knockout screening services
Probe gene function. Find drug targets. Stratify patients.
Ensuring library specificity with algorithm optimized guide RNA.
Custom services available for unique research projects.
Single-cell CRISPR screening
Identify the genetic interactions that underlie a treatment response with pooled CRISPR screening followed by single cell analysis.
CRISPR activation offers transient gain-of-function screening using endogenous expression mechanisms.
CRISPR interference screening offers transient loss-of-function screening with the accuracy of the CRISPR guide system.
Leveraging multiplatform cell-based screening for target ID
See the power of utilizing functional genomic and cell panel screening to produce greater insights that improve your target identification process with clearer identification of gene targets.
Overcoming hurdles in high-throughput profiling of cancer cell responses
Providing case studies on how FGS and CPS offer high-throughput solutions to find therapeutic targets, identify patient populations, uncover MoA, investigate drug combinations, and reveal drug resistance and sensitivity
Relevance of multiparametric screening to drug discovery efforts
Discover the importance of multiparametric screening to the drug discovery pipeline and how it's speeding up the whole process
CRISPR immune cell screens
Screening services for primary human immune cells.
Address clinically relevant biological questions in vitro.
Flexibility to scale to your needs
Select from whole genome or gene family catalog CRISPR and RNAi libraries or create a custom library in pooled or arrayed format.
How CRISPR-based functional genomics is transforming drug discovery
Explore how functional genomics enables researchers to explore further and how it's become a key tool in pre-clinical drug discovery.
Read how FGS is improving target identification, helping to understand drug response mechanisms, and being used for in vivo tumor biology.
App note: CRISPR-Cas9 screening to advance drug discovery
Read more about how CRISPR-Cas9 is a powerful approach to advance your drug discovery research. Exploring the various options and considerations to help you select the correct screening approach to suit your needs.
siRNA screening services
Benefit from rapid and efficient workflows.
Building on Dharmacon's 20+ years as the world leader in siRNA development, design and synthesis.
Functional genomic screening reading list
A compilation of publications that utilize Revvity’s functional genomic screening services. Covering areas around pooled screening, arrayed screening, CRISPR knockouts, CRISPR activation, CRISPR interference, and Dual CRISPRi/a screening.
Linking Genes to Phenotypes with CRISPR Screening
Read a literature review on the multiple CRIPSR screening techniques available for use in your workflow and their benefits
Functional genomic screening with CRISPR technologies