Pin-point™ Base Editing Services enable multiple genes of interest to be targeted simultaneously, efficiently, and accurately.
Pin-point™ base editing services for precise, controlled changes in target sequences to help advance your research and therapeutic development toward the clinic. By accessing services that utilize Pin-point base editing, you can improve cell viability and survival over traditional CRISPR technologies. Making systematic changes to gene sequences means you can effectively evaluate protein function, assess drug-gene interactions, and design optimal targets for amino acid modification and gene knockouts.
Functional genomic screening with the Pin-point base editing platform
Our platform provides a controlled evaluation of amino acid changes and/or the introduction of premature stop codons in a precise manner. Screens can be used to tile guide RNAs across an entire gene sequence to generate precise C-to-T mutations. T his information can then be used to select the best guide RNA(s) for potential therapeutic applications, identify critical amino acids in structure-function analysis, or to test ligand binding relationships in drug candidate screening and confirm target identity.
The Pin-point platform's novel three-part design offers unparalleled flexibility to "mix and match" individual system components, allowing full optimization of each targeted gene edit.
Benefits of the Pin-point platform include:
- Precise edits with clear and predictable mutations
- Safer for therapeutic use compared to traditional CRISPR
- No random mutations confounding results
- High viability for easier hit selection
- Ideal for sensitive cell lines like iPSCs