Pin-point™ Base Editing Services enable multiple genes of interest to be targeted simultaneously, efficiently, and accurately.
Pin-point™ base editing services for precise, controlled changes in target sequences to help advance your research and therapeutic development toward the clinic. By accessing services that utilize Pin-point base editing, you can improve cell viability and survival over traditional CRISPR technologies. Making systematic changes to gene sequences means you can effectively evaluate protein function, assess drug-gene interactions, and design optimal targets for amino acid modification and gene knockouts.
Functional genomic screening with the Pin-point base editing platform
Our platform provides a controlled evaluation of amino acid changes and/or the introduction of premature stop codons in a precise manner. Screens can be used to tile guide RNAs across an entire gene sequence to generate precise C-to-T mutations. T his information can then be used to select the best guide RNA(s) for potential therapeutic applications, identify critical amino acids in structure-function analysis, or to test ligand binding relationships in drug candidate screening and confirm target identity.
The Pin-point platform's novel three-part design offers unparalleled flexibility to "mix and match" individual system components, allowing full optimization of each targeted gene edit.
Benefits of the Pin-point platform include:
Precise edits with clear and predictable mutations
Safer for therapeutic use compared to traditional CRISPR 
No random mutations confounding results
High viability for easier hit selection
Ideal for sensitive cell lines like iPSCs