Pin-point™ Base Editing Services
is now part of Revvity’s portfolio

Workflow collaboration accelerating, creating a more complex cellular model

Pin-point™ Base Editing Services enable multiple genes of interest to be targeted simultaneously, efficiently, and accurately.

Pin-point™ base editing services for precise, controlled changes in target sequences to help advance your research and therapeutic development toward the clinic. By accessing services that utilize Pin-point base editing, you can improve cell viability and survival over traditional CRISPR technologies. Making systematic changes to gene sequences means you can effectively evaluate protein function, assess drug-gene interactions, and design optimal targets for amino acid modification and gene knockouts.

Functional genomic screening with the Pin-point base editing platform

Our platform provides a controlled evaluation of amino acid changes and/or the introduction of premature stop codons in a precise manner. Screens can be used to tile guide RNAs across an entire gene sequence to generate precise C-to-T mutations. T his information can then be used to select the best guide RNA(s) for potential therapeutic applications, identify critical amino acids in structure-function analysis, or to test ligand binding relationships in drug candidate screening and confirm target identity.

logo-mixer
The Pin-point platform's novel three-part design offers unparalleled flexibility to "mix and match" individual system components, allowing full optimization of each targeted gene edit.

base edit 

Benefits of the Pin-point platform include:

  • Precise edits with clear and predictable mutations
  • Safer for therapeutic use compared to traditional CRISPR
  • No random mutations confounding results
  • High viability for easier hit selection
  • Ideal for sensitive cell lines like iPSCs

The Pin-point platform can be used to:

  • Edit a gene sequence to determine critical amino acids for protein function
  • Edit cells that are typically sensitive to DNA damage in wild type CRISPR studies
  • Create single or multiplex mutations in cell models without the risk of genomic rearrangements

The Pin-point screening platform applications:

  • A pooled lentiviral screening approach
  • Tiled guide RNAs for C-to-T base changes across an entire target sequence
  • Custom guide RNA libraries designed by our team of experts to your gene(s) of interest
  • Next-generation sequencing reporting with bioinformatic analysis and hit nominations

Contact us to discuss your service needs

Required fields marked with * Required

Addressing the challenges in solid tumor therapy with base editing

Read about the key challenges in developing immunotherapeutics for solid tumors and how base editing is key to creating successful treatments

CRISPR-derived base editing technology: The what, the how, and the why

Learn everything you need to know about base editing, covering what it is, how it works, and the various applications it can be used for in gene and cell-based therapies

The future of immunotherapy gets brighter with base editing

A literature review discussing how base editing technology addresses the shortcomings of other gene editing technologies for immunotherapy